Cibolo Creek is a stream in South Central Texas, United States that runs approximately 96 miles from its source at Turkey Knob (in the Texas Hill Country) near Boerne, Texas, to its confluence with the San Antonio River in Karnes County. The creek serves as a tributary of the San Antonio River and forms the easternmost boundary of its watershed.
Several areas along the creek have been established for recreational use. Boerne City Park provides trails for hiking, nature walks, and horseback riding, and is a part of the larger Cibolo Nature Center. Several locations are available for fishing.